Several years ago our scientists developed a drug that blocks the formation of the ‘senile plaques’ that are found in the brains of patients with Alzheimer’s disease, the most common cause of dementia. This work is led by Professor David Allsop, who was the first person to isolate these plaques from the human brain.
The drug works by stopping single molecules of a substance called ‘Aβ’ from clustering together to form oligomers, which then aggregate further into ‘amyloid fibres’ that are found at the centre of the senile plaques. The oligomers and plaques cause damage to nerve cells, and lead to further changes in the brain that culminate in dementia.
You can read more about Professor Allsop’s research in the documents below.